Key Points
Atlanta N(Georgia) [US], October 27 (ANI): Researchers at Emory Universitys Winship Cancer Institute discovered a new form of immune cell known as the stem-like CD4 T cell, which plays an important role in anti-tumor immunity..
The pre-clinical findings, published in Nature, indicate the potential for activating these cells to combat tumours more effectively, providing new hope for broader treatment success, particularly in patients with cancer that are unresponsive to conventional immunotherapies...
Led by Haydn T. Kissick, PhD, a researcher in the Cancer Immunology Research Program at Winship Cancer Institute and assistant professor in the Department of Urology at Emory University School of Medicine, the study reveals that these stem-like CD4 T cells reside in the lymph nodes near tumours..
First author Maria Cardenas emphasizes the significance of overcoming this suppression: Most importantly while finding the immune system of patients with cancer in this idle state is common, we discovered that the stem-like CD4 T cell is capable of switching to an active state..
Researchers aim to use mRNA and lipid nanoparticle (LNP) technology to re-program these stem-like CD4 T cells, effectively removing the brakes on the immune response to cancer...
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