Study finds new target for treating heart failure

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Nagoya [Japan], September 15 (ANI): As society ages, the number of patients suffering from heart failure grows significantly..

Fibrosis, or excessive growth of fibrotic tissue in the heart, has been linked to the advancement of heart failure..

A group from Nagoya University Graduate School of Medicine in Japan discovered an enzyme called protein kinase N (PKN) that controls cardiac fibrosis...

However, in heart failure patients, they frequently cause extra tissue to collect, resulting in hardening of heart tissue and reduced function, a disease known as fibrosis..

Satoya Yoshida, Mikito Takefuji, and Toyoaki Murohara in the Department of Cardiology at the Nagoya University Graduate School of Medicine suspected the involvement of PKN in the changes of fibroblasts to myofibroblasts seen in fibrosis..