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Los Angeles (California) [US], April 23 (ANI): A genetic variation uncovered by Cedars-Sinai researchers increases the likelihood of getting perianal Crohns disease, the most devastating type of Crohns disease...
Fistulizing perianal Crohns disease can be a really miserable condition, said co-senior author Dermot McGovern, MD, PhD, director of Translational Research in the Cedars-Sinai F..
We have become much more successful in identifying genetic variants associated with the risk of developing diseases, but what we did here is specifically focused on a very complicated and severe manifestation of Crohns disease..
To discover genetic variants with a direct tie to this severe manifestation, investigators analyzed genetic data from three independent cohorts of patients with Crohns disease..
In the case where you have this mutation that leads to a nonfunctional protein, you dont get the normal signalling cascade, and the body doesnt recognize the bacteria as being harmful, and thus those bacteria are not eliminated, said co-senior author of the study Kathrin Michelsen, PhD, a research assistant professor of Medicine and Biomedical Sciences at Cedars-Sinai, adding, So, for those patients who have perianal Crohns disease, there are connections that form from the rectum to the skin area..
