Key Points
More than 2,000 regions on the human genome have been found to influence an individuals blood pressure and, in turn, their risk of developing hypertension, according to a new research...
Genomics is the study of an individuals entire genetic makeup, including the inter-relationships between genes, which are segments forming DNA that resides inside human cells...
Data from more than a million people were analysed to discover regions on the genome, including over a 100 new ones, linked to blood pressure. The international study, led by Queen Mary University of London in the UK, is published in the journal Nature Genetics...
Our study found additional genomic locations that together explain a much larger part of the genetic differences in peoples blood pressure. Knowing a persons risk for developing hypertension could lead to tailored treatments, which are more likely to be effective, first author Jacob Keaton, staff scientist at the National Human Genome Research Institutes in the US, said.. Several of the newly discovered genome locations were found to be within genes important for iron metabolism...
There are many different potential applications of genetic risk scores, so it will be exciting to see how our blood pressure scores can be used to address more clinically relevant questions in the future, last author Helen Warren, a senior lecturer in statistical genetics at Queen Mary University of London, said.. Our results provide new resources for understanding biological mechanisms and importantly new polygenic risk scores for early identification and stratification of people at risk for cardiovascular diseases, Patricia Munroe, a professor of molecular medicine at Queen Mary University of London, said...
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