Key Points
Tennessee [US], January 5 (ANI): The issue of antibiotic resistance in Mycobacterium abscessus (Mab) is being tackled by researchers at St. Jude Childrens Research Hospital..
To combat this, the researchers created novel spectinomycin formulations that circumvent efflux, the primary mechanism causing resistance..
Scientists at St. Jude modified the naturally occurring antibiotic spectinomycin to create analogs, comparable but structurally distinct N-ethylene linked aminomethyl spectinomycins (eAmSPCs)..
Over the past two decades, weve seen a massive increase in the number of infections caused by non-tuberculous mycobacteria like Mab, said co-first author Gregory Phelps, PharmD, St. Jude Graduate School of Biomedical Sciences..
The researchers also found that eAmSPCs work well with various classes of antibiotics used to treat Mab and retain their activity against other mycobacterial strains..
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