Key Points
Pittsburgh (Pennsylvania) [US], September 26 (ANI): A new study from the University of Pittsburgh School of Pharmacy provides light on the processes that contribute to liver fibrosis and proposes a unique therapy method for this prevalent and serious disorder...
The work, led by senior author Wen Xie, M.D., Ph.D., professor and Joseph Koslow endowed chair of the Department of Pharmaceutical Sciences, and co-first authors Hung-Chun Tung, graduate student, and Jong-Won Kim, Ph.D.,.
Preventive measures include avoiding excessive alcohol, maintaining a healthy body weight and early screening for liver diseases to prevent fibrosis from advancing to cirrhosis or liver failure...
Although the concentration of CYP1B1 in the whole liver is not high, this enzyme is uniquely and abundantly present in HSCs and thus plays an important role in HSC activation and liver fibrosis...
Our findings are clinically important because we identified CYP1B1 as a predictor of HSC and liver fibrosis in patients, which may help with the early diagnosis of this disease..
