Key Points
The pancreas failure to secrete adequate insulin appears to have been the trigger for type 2 diabetes in over half of the Indian patients (especially those diagnosed before the age of 45) in an Indo-Swedish study..
Researchers said this was the first study to investigate associations of European-derived genetic risk scores with type 2 diabetes, insulin-glucose indices, body composition and lipid-related traits in subgroups in India..
The collaboration, therefore, decided to study the genetics of type 2 diabetes subgroups of Indian and Swedish patients, not restricting to those diagnosed below the age of 45 years..
In addition, vitamin B12 deficiency-related genes were associated with the MOD subgroup only in Indians, not in the Swedish, Dr Yajnik said, adding that this suggests that the causes of type 2 diabetes differ between the two populations...
According to Dr Piyush Lodha, Diabetologist and General Physician at Ruby Hall Clinic , the findings of the study were important as the Indian population with type 2 diabetes has a different phenotype as compared to Caucasians likely due to genetic differences..
