Key Points
Published in the Proceedings of the National Academy of Sciences, the study delves into the cellular processes that allow cancer cells to proliferate even when targeted by anticancer drugs...
Cancer cells exploit cell cycles to multiply rapidly, a process known as proliferation..
The team led by Jean Cook of the Department of Biochemistry and Biophysics at University of North Carolina, Chapel Hill, identified a crucial enzyme that plays a key role in stopping cancer cell proliferation, particularly during treatment with anti-cancer drugs...
To explore protein degradations role in halting cell growth, Cook and graduate student Brandon Mouery treated cultured human cells with palbociclib, a metastatic breast cancer drug...
These findings could lead to new interventions that induce long-lasting proliferation arrest by exploiting this escape mechanism and cancer-associated DNA replication errors, potentially forcing cancer cells into a self-destructive growth mode...
