Key Points
Allergic asthma, which is characterized by wheezing and breathing difficulties triggered by inhaled allergens such as pollen, mould, and pet dander, is the most common chronic disease among children, and it can persist into adulthood..
New research led by investigators at Massachusetts General Hospital (MGH), a founding member of Mass General Brigham (MGB), reveals how the relationship between nerves and immune cells in the lungs can contribute to the development of this condition.. For the study, which is published in the Journal of Allergy & Clinical Immunology, scientists generated unique newborn mouse models of allergen exposure that reproduce the progression of allergic asthma from childhood to adulthood..
The work involved tracking allergen-specific immune cells called T helper 2 resident memory cells (Th2-TRMs) that are known to be the central mediator of recurrent allergic inflammation in the lungs..
Experiments revealed that sympathetic nerves in the lungs produce dopamine and reside in proximity to certain T helper 2 cells following allergen exposure in newborns..
"Since human lungs are similarly innervated by dopaminergic nerves in early postnatal life, the dopamine-DRD4 axis may provide a therapeutic target to modify allergic asthma progression from childhood to adulthood," says senior author Xingbin Ai, PhD, an investigator at MGH and an associate professor of Pediatrics at Harvard Medical School...
